Detection & Diagnostics

ATP Bioluminescence

applications of Bacteria detection

Water

Food

Surfaces

Biodefense

BTC is working collaboratively in the area of Bioluminescence - Detection of ATP from bacterial cells. The first assay is related to a generic bacterial detection system to determine general contamination. Through these efforts, we can identify specific bacteria with the inclusion of specific phage lytic enzymes (gram positive lytic enzyme detection).

The bioluminometer shown here is able to determine the presence of low levels of viable bacteria and as few as 100 spores. The system generally provides results within five minutes for bacterial detection and within 20 minutes for spore detection.

Features

FDA 510k Issued For Human Samples
DOD Validated
Validated For Carcass Contamination By USDA
Validated For Water Analysis By WHO Reference Laboratory
> 90% Correlation To Culture
Differentiate Bacterial And Non-bacterial Sources of ATP
Remove Interfering Substances & Free ATP

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

Plague Diagnostics Development

BTC is in the process of developing a rapid point-of-care assay to diagnose plague infections. This work is supported by US DOD to help reduce front line casualties from natural infections or possible bioweapons. This assay will be a multiplex lateral flow assay that detects two antigens from the bacteria causative for plague. The picture shows preliminary test results with purified antigens. With this assay, a test can be performed in 15 to 20 minutes with a drop of blood from a finger stick.

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

hand held assay (hha)

The SMART assay was the first rapid hand held assay developed in 1986 by the NHD team. In a new advancement to Hand Held Assays, the polymer enhanced SMART lateral flow assay provides an increase of up to 1 log in sensitivity as part of the first bio-defense test used since Desert Storm I in 1991. This new assay can be used for the detection of unknown bacteria, viruses and toxins for defense, food, animal or environmental applications.

“During the Gulf War we deployed 17 research and development systems to the Gulf region to monitor the air for suspected Iraqi Biological Warfare (BW) agents. Twelve of the 17 systems were mobile, and consisted of the Army’s XM-2 high volume air samplers and Sensitive Membrane Antigen Rapid Test (SMART) identification tickets.”

— General Norman Schwarzkopf

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

selected Lateral Flow Assays (smart ii)

Enhanced lateral flow technology with polymer-enhanced gold nanoparticles and optimized other parameters including protein concentrations, solution components and treatment conditions.

Polymer of Enhancement of Gold Nanoparticle Conjugation with Antibody

Polymer Enhancement of Gold Nanoparticle Conjugation With Antibody

TB LAM

Cholera

Anthrax Spore

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

Rapid Detection

BTC and NHDetect are teaming to offer products focused on the rapid detection of bacteria, viruses and toxins.

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

Medical Applications

Cholera DFA and Bengal DFA
Staining Kits for Vibrio cholerae-O1 and Vibrio cholerae-O139

SMART^TM II Cholera O1

The test kit is comprised of the Cholera DFA reagent and two control reagents. Water samples are concentrated and a sample is fixed onto a microscope slide. The test sample and control samples are then incubated with the DFA reagent. If the sample contains V. cholerae O1, the FITC-labeled monoclonal antibody will bind V. cholerae O1. After washing, the slide is examined under the fluorescent microscope.

Features

96% Sensitivity
99% Specificity for Vibrio Cholerae O1
Simple Procedure
No Culture Required (allows water, food or stool sampling)
Less Than 10 Minutes Test Time
Less Than 20 Seconds Technician Time
Detect As Few As 2 x 10⁵ Organisms
Reagents Lyophilized in One Tube
Distinct Color Reaction on Captured Membrane

Application Download

GonoGen^TM II - Neisseria Gonorrhea

GonoGen^TM II

GonoGen^TM II is a monoclonal antibody-based colorimetric test intended for the confirmatory identification of Neisseria gonorrhea. The test requires less than two minutes to perform with no heating or pretreatment. GONOGEN II is highly specific, can be utilized with specimens from all body sites, and does not require isolated, viable or fresh cultures. GonoGen^TM II eliminates agglutination "guesswork" by developing a clear-cut color reaction.

Features

Monoclonal Antibody-Based Assay
99% Specific for Neisseria Gonorrhea
100% Sensitive
Effective with Mixed or Non-viable Cultures
No Heating
Single or Batch Testing
No Agglutination Guesswork
Clear-cut Color Reaction
Detects GC Where Routine Sugars and FA's May Not, Even on Cultures in Transit Over 10 Days

Application Download

GonoGen II

TRUST (Syphilis) - Toluidine Red Unheated Serum Test

TRUST is CDC approved as a STANDARD STATUS TEST for the Quantitative and Qualitative serologic detection of Syphilis. Smooth negatives are attained by the use of a dye (toluidine red unheated serum) versus the inconsistencies of burned charcoal. Room temperature storage, no glass ampoules, and cost-effective pricing make TRUST a sensitive and specific alternative for RPR and other more expensive nontreponemal tests for Syphilis.

Features

CDC Approved STANDARD STATUS Test
Easy to Perform Standard RPR Procedure
Cost Effective: Savings Over Standard RPR Test
Room Temperature Storage
No Glass Ampoules to Break
Single or Batch Testing
Quantitative and Qualitative Procedure
Sensitive and Specific Replacement for the Standard RPR Test

Application Download

TRUST (Toluidine Red Unheated Serum Test)

PROFILE^TM 1 with Model 3560 Bioluminometer

PROFILE^TM 1 Bioluminometer Model 4550

New Horizons Diagnostics (NHD) manufactures tests for the rapid detection of bacteria and toxins in human, environmental, surface, food, and water samples. NHD’s luminescence-based PROFILE SYSTEM has been USDA-validated to detect low-levels of bacteria with results that correlate to a 24-48 hour culture. The PROFILE SYSTEM is also able to differentiate microbial from somatic cells, yeast from bacteria, and can eliminate interfering (quenching) substances from the sample in less than five minutes. Utilizing an incubation process to render spores to a vegetative state, our Model 3560 can also detect the presence of spores.

Features

Provides Reliable, Near Real-time Detection of Bacteria
Accuracy of a 48-Hour Culture in Less Than Five Minutes
Discriminates Bacterial ATP from Total ATP
Eliminates Quenching Substances from Sample
Hand-held, Battery-powered

Models

Bioluminometer (Model 3560)
Tests for the rapid detection of bacteria and toxins in human, environmental, surface, food, and water samples. Discriminates between total ATP and bacterial ATP.
Bioluminometer (Model 3550i)
Utilizing an incubation process to render spores to a vegetative state, Model 3550i detects the presence of spores.
Bioluminometer (Model 4550)
The total ATP is solid phased (the luciferin-luciferase is freeze-dried onto a membrane). This method is quick, easy and sensitive.

Application Download

PROFILE^TM 1 Bioluminometer Model 3560

Biothreat Detection

Diagnostic Kits

Anthrax (Spore) SMART^TM II

Bacillus Anthracis (Spore) Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Anthrax (Spore) SMART^TM II is designed to detect the bacillus anthracis spore from environmental samples. It is not intended to be used in the diagnosis of anthrax or any other disease.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, results should be confirmed by an alternative method.

Materials Included Per Pouch:

Anthrax Spore Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Caution: For assay to function properly, NHD’s SWIPE or a validated collection system must be utilized to properly collect and process the sample. Failure to utilize a proper collection system may cause false negative or false positive results.

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of Anthrax Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Application Download

Anthrax (Spore) SMART^TM II

Cholera SMART^TM II - Vibrio cholerae-O1

Cholera SMART^TM II

Cholera SMART^TM II is a lateral flow, colorimetric immunoassay designed for the direct presumptive detection of Vibrio cholerae-O1 in clinical samples as an adjunct to classical culture methods. Simply collect the patient’s specimen and place in Specimen Filtering Device (follow dilution guidelines to ensure proper liquid form). Place four (4) drops in the Sample Well of the SMART II cassette followed in about 3 minutes with 2 drops of Chase Buffer. Read results in 15 minutes.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on the Captured Membrane

Application Download

Ricin SMART^TM II

Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Ricin SMART^TM II is designed to detect the RICIN toxin from environmental samples. It is not intended to be used in the treatment of any human/animal disease or illness.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, results should be confirmed by another method.

Materials Included:

RICIN Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of RICIN Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Application Download

Ricin Assay Instructions

Staph Enterotoxin B SMART^TM II

SEB Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Staph Enterotoxin B SMART^TM II is designed to detect the Staph Enterotoxin B from environmental samples. It is not intended for use in the diagnosis or treatment of any human/animal disease or illness.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, results should be confirmed by an alternative method.

Materials Included Per Pouch:

Staph Enterotoxin B Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of Staph Enterotoxin B Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Application Download

Staph Enterotoxin B

Yersina Pestis (F1) SMART^TM II

Yersina Pestis (plague) Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Yersina Pestis (F1) SMART^TM II is designed to detect the Yersina Pestis from environmental samples. It is not intended to be used in the diagnosis of plague or any other disease.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, results should be confirmed by an alternative method.

Materials Included Per Pouch:

Yersina Pestis Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of Yersina Pestis Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on Captured Membrane

Application Download

SMART^TM II Yersina Pestis (F1) (Plague)

Tularemia SMART^TM II

Francisella Tularensis Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Tularemia SMART^TM II is designed to detect the Francisella tularensis in environmental samples. It is NOT intended to be used in the diagnosis of tularemia or any other human or animal disease. This test is a rapid, screening assay.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, positive results should be confirmed by an alternative method.

Materials Included Per Pouch:

Francisella Tularensis Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of Francisella Tularensis Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on Captured Membrane

Application Download

Tularemia SMART^TM II

Botulism Toxin A SMART^TM -II

Botulism Toxin A Lateral Flow Screening Assay
This is for environmental use only, not for human use.

Intended Use:
Botulism Toxin A SMART^TM II is designed to detect the botulism toxin "A" from environmental samples. It is not intended for use in the diagnosis of treatment of any human/animal disease or illness.

Caution:
This test is a rapid, screening assay. No known rapid screening assay is 100% sensitive or 100% specific; therefore, results should be confirmed by an alternative method.

Materials Included Per Pouch:

Botulism Toxin Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Collection Kits NOT Included:

(To collect a sample, you should use one of the following kits or its equivalent.)

Large Surface Sample Collection Kit, (SWIPE-1), Reorder No. 87-130001
Powder/Small Surface Sample Collection Kit, (SWIPE-2), Reorder No. 87-130002
Liquid Sample Collection Kit, (SWIPE-3), Reorder No. 87-130003
Air Sampler Sample Collection Kit, (SWIPE-4), Reorder No. 87-130004

If the sample has debris or large particles, it may require use of the SPK:

Sample Processing Kit: SWIPE-SPK, Reorder No. 87-130100

Assay Procedure:

Collect Samples and Follow Dilution Guidelines to Ensure Sample is in a Liquid Form.
Open Pouch of Botulism Toxin A Lateral Flow Device; Remove Contents.
Place Three (3) Drops (or 100µl) of Liquid Sample into Sample Well of a Lateral Flow Device Using Plastic Dropper Provided.
Wait Three (3) Minutes for the Sample to Be Absorbed into the Sample Well. Then Place Two (2) Free Falling Drops of Chase Buffer from the Dropper Bottle.
Read Results at 15 Minutes (No Longer Than 30 Minutes). Observe the Development of Color on the Control (C) and Test Line (T) and Record Results. For more information, download accompanying PDF file.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on Captured Membrane
Proven Technology - "Desert Storm Tested"

Application Download

Botulism Toxin A SMART^TM-II

Collection Kits

Sample Processing Kit

Environmental

PROFILE^TM 1 with Model 3560 Bioluminometer

PROFILE^TM 1 Bioluminometer Model 4550

Features

Provides Reliable, Near Real-time Detection of Bacteria
Accuracy of a 48-Hour Culture in Less Than Five Minutes
Discriminates Bacterial ATP from Total ATP
Eliminates Quenching Substances from Sample
Hand-held, Battery-powered

Models

Bioluminometer (Model 3560)
Tests for the rapid detection of bacteria and toxins in human, environmental, surface, food, and water samples. Discriminates between total ATP and bacterial ATP.
Bioluminometer (Model 3550i)
Utilizing an incubation process to render spores to a vegetative state, Model 3550i detects the presence of spores.
Bioluminometer (Model 4550)
The total ATP is solid phased (the luciferin-luciferase is freeze-dried onto a membrane). This method is quick, easy and sensitive.

Application Download

PROFILE^TM 1 Bioluminometer Model 3560

Bioavailable Ferric Iron Assay

Natural attenuation can be a technically, environmentally and economically preferred choice for remediation of hydrocarbon and chlorinated hydrocarbon contaminants at suitable sites. Ferric-iron-reducing bacteria can degrade benzene, vinyl chloride, and other contaminants if adequate BIOAVAILABLE Iron is present. The test is used in conjunction with other accepted tests to evaluate site suitability for natural attenuation, and for monitoring effectiveness and efficiency of ongoing natural attenuation.

The Bioavailable Ferric Iron Assay measures the amount of ferric iron in soil or sediment that can be reduced to ferrous iron (Fe2+) by iron-reducing bacteria. Bioavailable ferric iron is one indicator of natural attenuation and can be important for other in situ bioremediation technologies such as enhanced anaerobic bioremediation.

Developed by Camp Dresser & McKee and available through New Horizons Diagnostics, this Field Test Kit offers direct determination of Bioavailable Iron and is:

Francisella Tularensis Lateral Flow Test Devices
Plastic Droppers
Chase Buffer

Bioavailable Ferric Iron Assay Simple Procedure

Developed by: CDM Camp Dresser & McKee Inc.

Profile^TM 1

Ferric Iron Assay

Food Testing

SMART^TM II E. coli Food Test

SMART - II™ FOOD TESTS for E. coli & Salmonella

SMART^TM II Food Tests are rapid, non-culture, diagnostic, immunochromatographic assays for the qualitative detection of the presence of E-coli and Salmonella from a food sample pre-enriched in a selective medium.

The SMART^TM-II Rapid E. coli O157 Strip Test is a rapid, non-culture diagnostic assay that can detect the presence of this organism from a food sample pre-enriched in a selective medium (i.e., EC modified media). It is an immunochromatographic assay employing a colloidal, gold labeled anti-E. coli O157:H7 antibody as a visual marker for the presence of the specific antigen. The test area of the assay strip is coated with a line of immobilized anti. E. coli O157:H7 antibody. During the assay, the (enriched) food sample contacts an absorbent pad coated with an extraction reagent to release antigen from intact organisms. This mixture reacts with the conjugate (anti-E. coli O157:H7 antibody-colloidal gold) that is dried on the assay strip. The mixture diffuses upward on the nitrocellulose membrane chromatographically by capillary action.

If antigen is present in the sample, a positive result will be visually observed by the formation of a colored band consisting of a specific antibody-antigen conjugate complex at the TEST region of the membrane. Absence of this band at the TEST region suggests a NEGATIVE assay result. A CONTROL line (anti-goat IgG) is present on the strip to demonstrate proper test performance. The CONTROL line indicates the test is performing properly. Absence of this band prevents Interpretation of the test.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on the Captured Membrane

SMART^TM II Salmonella Food Test

SMART^TM II Food Tests are rapid, non-culture, diagnostic, immunochromatographic assays for the qualitative detection of the presence of E-coli and Salmonella from a food sample pre-enriched in a selective medium.

The SMART^TM-II Rapid Salmonella Strip Test is a rapid, non-culture diagnostic assay that can detect the presence of this organism from a food sample pre-enriched in a selective medium. It is an immunochromatographic assay employing a colloidal, gold-labeled anti-Salmonella antibody as a visual marker for the presence of the specific antigen. The test area of the assay strip is coated with a line of immobilized anti. Salmonella antibody. During the assay, the (enriched) food sample contacts an absorbent pad coated with an extraction reagent to release antigen from intact organisms. This mixture reacts with the conjugate (anti-Salmonella antibody-colloidal gold) that is dried on the assay strip. The mixture diffuses upward on the nitrocellulose membrane chromatographically by capillary action.

If antigen is present in the specimen, a positive result will be visually observed by the formation of a colored band consisting of a specific antibody-antigen conjugate complex at the TEST region of the membrane. Absence of this band at the TEST region suggests a NEGATIVE assay result. A CONTROL line (anti-goat IgG) is present on the strip to demonstrate proper test performance. The CONTROL line indicates the test is performing properly. Absence of this band prevents Interpretation of the test.

Features

Less Than 20 Seconds Technician Time
Room Temperature Storage
Distinct Color Reaction on the Captured Membrane

PROFILE^TM 1 with Model 3560 Bioluminometer

PROFILE^TM 1 Bioluminometer Model 4550

Features

Provides Reliable, Near Real-time Detection of Bacteria
Accuracy of a 48-Hour Culture in Less Than Five Minutes
Discriminates Bacterial ATP from Total ATP
Eliminates Quenching Substances from Sample
Hand-held, Battery-powered

Models

Bioluminometer (Model 3560)
Tests for the rapid detection of bacteria and toxins in human, environmental, surface, food, and water samples. Discriminates between total ATP and bacterial ATP.
Bioluminometer (Model 3550i)
Utilizing an incubation process to render spores to a vegetative state, Model 3550i detects the presence of spores.
Bioluminometer (Model 4550)
The total ATP is solid phased (the luciferin-luciferase is freeze-dried onto a membrane). This method is quick, easy and sensitive.

Application Download

PROFILE^TM 1 Bioluminometer Model 3560

E-coli

Salmonella

Profile^TM 1

Fluorescence Immunoassay System

BTC also is working with partners on the development of a Membrane Enhanced Fluorescence Immunoassay System with specific monoclonal antibodies for the rapid and sensitive detection of bacteria, viruses and toxins based on immunological (antibody-antigen) reactions. A combined 180 degree optical/membrane configuration will be employed for rapid, high sensitivity and simple determination of low concentrations of target substances such as bacteria, spores and viruses.

The fluorescence antibody mixture is immobilized on a carefully selected translucent membrane with appropriately low fluorescence background and high sensitivity characteristics.

Operational Capability

< 1 lb, 6" x 3" x 1.5", Battery Powered
Glucose Like Strip 2 Step Method < 3 minutes Total Time
Stability > 1 Year
Sensitivity Equal To or Greater Than Current Methods
Rugged Field Usable
Download And Data Configuration Capable (Future)

For more information contact:

Dr. Yingyun Liu
Brimrose Technology Corporation
410-472-2600

Detection & Diagnostics

ATP Bioluminescence

applications of Bacteria detection

Features

Plague Diagnostics Development

hand held assay (hha)

selected Lateral Flow Assays (smart ii)

Rapid Detection

Cholera DFA and Bengal DFAStaining Kits for Vibrio cholerae-O1 and Vibrio cholerae-O139

Features

Application Download

GonoGen TM II - Neisseria Gonorrhea

Features

Application Download

TRUST (Syphilis) - Toluidine Red Unheated Serum Test

Features

Application Download

PROFILE TM 1 with Model 3560 Bioluminometer

Features

Models

Application Download

Anthrax (Spore) SMART TM II

Application Download

Cholera SMART TM II - Vibrio cholerae-O1

Features

Application Download

Ricin SMART TM II

Application Download

Staph Enterotoxin B SMART TM II

Application Download

Yersina Pestis (F1) SMART TM II

Features

Application Download

Tularemia SMART TM II

Features

Application Download

Botulism Toxin A SMART TM -II

Features

Application Download

SWIPE TM 1 Large Surface Sample Collection Kit

SWIPE TM 2 Powder/Small Surface Sample Collection Kit

SWIPE TM 3 Liquid Sample Collection Kit

SWIPE TM 4 Air Sampler Sample Collection Kit

SWIPE TM SPK Sample Processing Kit

PROFILE TM 1 with Model 3560 Bioluminometer

Features

Models

Application Download

Bioavailable Ferric Iron Assay

SMART TM II E. coli Food Test

Features

SMART TM II Salmonella Food Test

Features

PROFILE TM 1 with Model 3560 Bioluminometer

Features

Models

Application Download

Fluorescence Immunoassay System

Operational Capability

contact info

core science

🔗 links

Cholera DFA and Bengal DFA
Staining Kits for Vibrio cholerae-O1 and Vibrio cholerae-O139

GonoGen^TM II - Neisseria Gonorrhea

PROFILE^TM 1 with Model 3560 Bioluminometer

Anthrax (Spore) SMART^TM II

Cholera SMART^TM II - Vibrio cholerae-O1

Ricin SMART^TM II

Staph Enterotoxin B SMART^TM II

Yersina Pestis (F1) SMART^TM II

Tularemia SMART^TM II

Botulism Toxin A SMART^TM -II

SWIPE^TM 1 Large Surface Sample Collection Kit

SWIPE^TM 2 Powder/Small Surface Sample Collection Kit

SWIPE^TM 3 Liquid Sample Collection Kit

SWIPE^TM 4 Air Sampler Sample Collection Kit

SWIPE^TM SPK Sample Processing Kit

PROFILE^TM 1 with Model 3560 Bioluminometer

SMART^TM II E. coli Food Test

SMART^TM II Salmonella Food Test

PROFILE^TM 1 with Model 3560 Bioluminometer